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The comatose, vegetative, and locked-in-states are treatable conditions. The medications used to treat these conditions are safe for most patients, though cardiac disease may significantly increase risks with sympathomimetics and this class of psychostimulants should be considered a tertiary option in this population. Psychostimulants are broadly classified in terms of neurotransmitter agonism, including noradrenergic, dopaminergic, and serotonergic. COGNITION - SUBOPTIMAL AROUSAL. Once a patient is awak...

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Aaron Geller, M.D.

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The comatose, vegetative, and locked-in-states are treatable conditions. The medications used to treat these conditions are safe for most patients, though cardiac disease may significantly increase risks with sympathomimetics and this class of psychostimulants should be considered a tertiary option in this population. Psychostimulants are broadly classified in terms of neurotransmitter agonism, including noradrenergic, dopaminergic, and serotonergic. COGNITION - SUBOPTIMAL AROUSAL. Once a patient is awak...
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The comatose, vegetative, and locked-in-states are treatable conditions. The medications used to treat these conditions are safe for most patients, though cardiac disease may significantly increase risks with sympathomimetics and this class of psychostimulants should be considered a tertiary option in this population. Psychostimulants are broadly classified in terms of neurotransmitter agonism, including noradrenergic, dopaminergic, and serotonergic. COGNITION - SUBOPTIMAL AROUSAL. Once a patient is awak...

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1

Disclaimer

http://www.comawakening.com/disclaimer.html

COGNITION - SUBOPTIMAL AROUSAL. FOLLOW UP AND FUTURE DIRECTION. This web site is constantly being updated and evolving as new pain related research is reviewed. As this site was hastened to be posted at the request of numerous patients, the visitor is requested to appreciate that grammatical corrections and redundancy will be corrected, and addition of pending references will be forthcoming. Treating the Comatose, Vegetative, and. Aaron S. Geller, M.D., Medical Director and President. It is the pinnacle ...

2

INITIAL TREATMENT

http://www.comawakening.com/initial-treatment.html

COGNITION - SUBOPTIMAL AROUSAL. FOLLOW UP AND FUTURE DIRECTION. Caloric, mineral, fluid, and protein malnutrition will negatively impact cognition. Folate, thiamine, and other vitamins are requisite to cortical processing, and may require supplementation. Body weights, pre-albumin levels, hemoglobin levels, vitamin levels, and calorie counts require monitoring and may suggest the indication for gastrostomy placement. Avoid complex, stressful activities to which the disinhibited patient may combatively re...

3

Home

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The comatose, vegetative, and locked-in-states are treatable conditions. The medications used to treat these conditions are safe for most patients, though cardiac disease may significantly increase risks with sympathomimetics and this class of psychostimulants should be considered a tertiary option in this population. Psychostimulants are broadly classified in terms of neurotransmitter agonism, including noradrenergic, dopaminergic, and serotonergic. COGNITION - SUBOPTIMAL AROUSAL. Once a patient is awak...

4

REFERENCES

http://www.comawakening.com/references.html

COGNITION - SUBOPTIMAL AROUSAL. FOLLOW UP AND FUTURE DIRECTION. 1 Martini E, et al.: Brief information on an early phase II study with deprenyl in demented patients. Pharmacopsychiatry. 20:256-7, 1987. 2 Evans RW, Gualtieri CT: Psychostimulant pharmacology in traumatic brain injury. J Head Trauma Rehabil 2(4):29-33, 1987. 3 Crisostomo EA, et al.: Evidence that amphetamine with physical therapy promotes recovery of motor function in stroke patients. Ann Neurol 23:94-7, 1988. 12 Gupta SR, Mlcoch AG: Bromoc...

5

MEDICATIONS

http://www.comawakening.com/medications.html

COGNITION - SUBOPTIMAL AROUSAL. FOLLOW UP AND FUTURE DIRECTION. MEDICATION TRIALS - SPECIFIC AGENTS. Noradrenergic agents such as amphetamine facilitate AAI via enhancing presynaptic release(15) of endogenous stores and decreasing presynaptic reuptake(34) of dopamine and norepinephrine catecholamines. Dextroamphetamine, methylphenidate, desipramine, protriptyline, and pemoline are therapeutic options. Dextroamphetamine (Dexedrine) is felt to directly enhance endogenous presynaptic release of dopamine(46,...

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The comatose, vegetative, and locked-in-states are treatable conditions. The medications used to treat these conditions are safe for most patients, though cardiac disease may significantly increase risks with sympathomimetics and this class of psychostimulants should be considered a tertiary option in this population. Psychostimulants are broadly classified in terms of neurotransmitter agonism, including noradrenergic, dopaminergic, and serotonergic. COGNITION - SUBOPTIMAL AROUSAL. Once a patient is awak...

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