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DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia. Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia. USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA. Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.

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Skip to main content. Skip to secondary content. Mr Isaac's Blog. A day in the life of one baby and his minions. Who is Mr Isaac? July 30, 2012. Isaac loves the flower beds:-) as soon as we go in the garden his face lights up and he speedily crawls to them! He likes to play with the soil, pick the flowers and try to eat them-but then pulls a disgusted face and spits them out! I’m linking up to Coombe Mill. July 29, 2012. July 15, 2012. July 8, 2012. July 1, 2012. June 24, 2012. June 20, 2012. It has to b...

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