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Genome-wide analysis of mammalian promoter architecture and evolution - Nature Genetics

http://www.nature.com/ng/journal/vaop/ncurrent/abs/ng1789.html

Nature Reviews Molecular Cell Biology. 626 - 635 (2006). Published online: 28 April 2006; Corrected online: 05 May 2006; Corrected online: 29 August 2007 doi:10.1038/ng1789. There is a Corrigendum. September 2007) associated with this Article. Genome-wide analysis of mammalian promoter architecture and evolution. Colin A M Semple. Pär G Engström. Alistair R R Forrest. Genome Science Laboratory, Discovery Research Institute, RIKEN Wako Institute, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan. Broadband Com...

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Double Dutch for duplications : Abstract : Nature Genetics

http://www.nature.com/ng/journal/v39/n11/abs/ng1107-1303.html

Jump to main content. 1303 - 1304 (2007). Double Dutch for duplications. Ewan Birney is at the European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom. E-mail: birney@ebi.ac.uk. A new study presents a comprehensive global analysis of the evolution of segmental duplications in the human genome. The authors identify the origin of ancestral duplication loci, regions of clustered duplicons, and evidence supporting a punctuated model of evolution.

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T: (brachyury) gene duplication confers major susceptibility to familial chordoma : Abstract : Nature Genetics

http://www.nature.com/ng/journal/v41/n11/abs/ng.454.html

Jump to main content. 1176 - 1178 (2009). Published online: 4 October 2009. Brachyury) gene duplication confers major susceptibility to familial chordoma. Using high-resolution array-CGH, we identified unique duplications of a region on 6q27 in four multiplex families with at least three cases of chordoma, a cancer of presumed notochordal origin. The duplicated region contains only the T. Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA. Correspondence to: Dilys M Parry.

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Common variation in : KITLG: and at 5q31.3 predisposes to testicular germ cell cancer : Abstract : Nature Genetics

http://www.nature.com/ng/journal/v41/n7/abs/ng.393.html

Jump to main content. 811 - 815 (2009). Published online: 31 May 2009. Common variation in KITLG. And at 5q31.3 predisposes to testicular germ cell cancer. Testicular germ cell tumors (TGCT) have been expected to have a strong underlying genetic component. We conducted a genome-wide scan among 277 TGCT cases and 919 controls and found that seven markers at 12p22 within KITLG. C-KIT ligand) reached genome-wide significance ( P. Sprouty 4; P. As genes involved in TGCT susceptibility. Abramson Cancer Center...

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The draft genome of the fast-growing non-timber forest species moso bamboo (Phyllostachys heterocycla) : Nature Genetics : Nature Research

http://www.nature.com/ng/journal/v45/n4/full/ng.2569.html

Jump to main content. Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and…. OsLG1 regulates a closed panicle trait in domesticated rice. The draft genome of the fast-growing non-timber forest species moso bamboo ( Phyllostachys heterocycla. Download as PDF (919 KB). View interactive PDF in ReadCube. Assemblies and comparative genomics. Genome duplication in grass genomes. The calculated K. Mutations per site per year. Evolution of orthologo...

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Genome and transcriptome of the porcine whipworm Trichuris suis : Nature Genetics : Nature Research

http://www.nature.com/ng/journal/v46/n7/full/ng.3012.html

Jump to main content. Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction. A reference genome for common bean and genome-wide analysis of dual domestications. Genome and transcriptome of the porcine whipworm Trichuris suis. Download as PDF (1,194 KB). View interactive PDF in ReadCube. And 80-Mb draft assemblies. We explore stage-, sex- and tissue-specific transcription of mRNAs and small noncoding RNAs. X02264; 0.05; Pearson&#x...

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Journal home : Nature Genetics

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Jump to main content. Article 15 August 2016. Single-cell chromatin accessibility in human hematopoiesis and leukemia evolution. Ryan Corces, Jason Buenrostro et al. Howard Chang, Ravindra Majeti and colleagues define chromatin accessibility and transcriptional landscapes in 13 human primary blood cell types and in acute myeloid leukemia cells. They identify potential regulators governing hematopoietic differentiation and genetic elements linked to regulatory evolution in cancer cells. Ruli Gao et al.

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Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris - Nature Genetics

http://www.nature.com/ng/journal/v38/n3/abs/ng1743.html

Nature Reviews Molecular Cell Biology. 337 - 342 (2006). Published online: 29 January 2006; doi:10.1038/ng1743. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Frances J D Smith. W H Irwin McLean. Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. Department of Paediatric Dermatology, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland.

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The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line : Abstract : Nature Genetics

http://www.nature.com/ng/journal/v41/n5/abs/ng.375.html

Jump to main content. 553 - 562 (2009). Published online: 19 April 2009. The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. The FANTOM Consortium and Riken Omics Science Center. Regulatory sites, we identified the key transcription regulators, their time-dependent activities and target genes. Systematic siRNA knockdown of 52 transcription factors confirmed the roles of individual factors in the regulatory network. Our results indicat...South...

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Genome-wide association study of hematological and biochemical traits in a Japanese population : Nature Genetics : Nature Research

http://www.nature.com/ng/journal/vaop/ncurrent/abs/ng.531.html

Jump to main content. A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay. Identification of DOK genes as lung tumor suppressors. Genome-wide association study of hematological and biochemical traits in a Japanese population. View interactive PDF in ReadCube. 60; 5 × 10. Values less than 0.05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated. Am J Hum. Genet. Thein, S.L. Intergenic variants of HBS1L-MYB are resp...