orthweinlab.com
Main - Orthwein LabOrthwein Lab is located in the Lady Davis Institute at Montreal’s Jewish General Hospital.
http://www.orthweinlab.com/
Orthwein Lab is located in the Lady Davis Institute at Montreal’s Jewish General Hospital.
http://www.orthweinlab.com/
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Main - Orthwein Lab | orthweinlab.com Reviews
https://orthweinlab.com
Orthwein Lab is located in the Lady Davis Institute at Montreal’s Jewish General Hospital.
orthweinlab.com
About - Orthwein Lab
http://www.orthweinlab.com/en/about
A double-edged sword in using DNA damage for B-cells. B-cells are central components of the adaptive immune response and play a key role in protecting humans from infections. They require programmed DNA lesions, in particular DNA double-strand breaks (DSBs), to become functional. Unfortunately, these lesions can trigger genomic rearrangements that fuel cancers of B-cell, including lymphoma, leukemia and multiple myeloma.
Publications - Orthwein Lab
http://www.orthweinlab.com/en/publications
HELB is a feedback inhibitor of DNA end resection. Tkac J*, Xu G*, Adhikary H, Young JTF, Escribano-Diaz C, Krietsch J, Orthwein A. Munro M, Sol W, Al-Hakim A, Lin ZY, Jonkers J, Piet B, Gingras AC, Rottenberg S, Masson JY, Durocher D. (* co-first authors). A mechanism for the suppression of homologous recombination in G1 cells. HSP90 inhibitors decrease AID levels and activity in mice and human cells. Eur J Immunol (2015). Montamat-Sicotte D, Safavi S, Abreu C, Litzler LC, Zahn A, Orthwein. A cell cycle...
People - Orthwein Lab
http://www.orthweinlab.com/en/people
We are always looking for highly motivated and talented individuals to join our lab! If you are interested in our research, get in touch with us! BSc (Université Louis Pasteur, Strasbourg), M.Sc. and Ph.D. (Université de Montréal). BSc (ESTBA, Paris), M.Sc. Microbio/Immuno (U of Montreal). BSc Biochem. (U. of Quebec), M.Sc/PhD in Vision Sc./Cell and Molecular Biology (U. of Montreal). BSc Pharmacy (Jordan U. of Sci and Tech), M.Sc. Biomedical Sciences (U. of Montreal).
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